The New Antipsychotics
SPG302 a compound that regrows certain kinds of synapses gave me the first real opportunity at being free from traditional antipsychotics. Upon initiation I felt a strong sedation that was too reminiscent of being on too a dose of antipsychotics. Note that to maintain sanity prior to this I was on 10mg Olanzapine and 25mg Aripiprazole, a very high net dose. Upon suspecting that this sedation may be alleviated by lowering anti psychotics I tried just that. I went lower and lower. Sedation went away and my positive symptoms were relatively stable. Note that in the absence of SPG302 this had been tried and any reduction to olanzapine would cause erratic behavior, noise and disorganisation of thoughts. SPG302 now has a name its called Tazbentetol and good results have been posted in the SZ trial which particularly showed improvements in positive symptoms. In line with my experience.
However this was not enough. My concentration was poor and sanity was not quite there. (nor was it completely there with Olz and Arip)
Enter Xanomeline (Cobenfy)
I had aquired Xanomeline the main ingredient in Cobenfy which is now approved several years prior. It had made me very irritable whilst on antipsychotics so it was shelved. But this time together with SPG302 it restored almost everything. I was sharp, motivated and had a clear head. But I could not do mathematics. It turns out stimulation of M4 receptor severs a retrival system from the hippocampus thats normally overactive in SZ so doing this makes you sane but also causes certain cognitive deficits. For me this meant I could not do mathematics or study. numbers made no sense and I couldnt recall anything i had learnt. I could not think visually like I used to prior to the illness. at a low dose of Xano this is restored however I am emotionally and cognitively unstable. note that my xanomeline is an oxalate and not the same salt as cobenfy so doses cannot be compared.
Enter Emracladine
This is a M4 PAM which means it makes the receptor more sensitive to endogenous neurotransmitters. Which in theory means that in this case it wouldnt totally sever the retrieval process but simply dampen it. And it did just that. Emracladine by itself is probably too weak, and so it didnt do too well in trials however it certainly had significant effects which the trials confirmed.
So currently the reason I am sane and stable is due to these 3 drugs and various supplemental compounds which have mild effects. Namely Ashwaghanda, Phosphatidyl serine and Sarcosine. Supplemental compounds have solid effect which allow doses of the other key compounds to be a bit lower but they alone would be useless. note even these compounds have been dialed in, with various doses tested.